DETECTION OF QUINOLONE RESISTANCE AMONG ENTERIC FEVER SALMONELLAE

Dr. Rajeshwari K G

Dr. Raghavendra Rao M

Dr Sumana M N

Dr. Madhuri Kulkarni

Dr. Ranjitha S Gowda

Vol. 1, Issue 1, Jan-Dec 2015

Page Number: 32 - 40

Abstract:

Enteric fever is an important public health problem in developing countries like India. Antibiotics are still the main stay in the treatment of enteric fever, but enteric fever Salmonellae have developed drug resistance and this has further hampered the process of reducing the mortality & morbidity associated with this disease. Materials & Methods: Phenotypically & serologically confirmed enteric fever Salmonellae were subjected for antimicrobial susceptibility testing by Kirby Bauer disc diffusion testing & MIC of the Salmonellae were detected using Agar dilution, E test & Hi comb. Results: 8.46% of samples received for blood culture yielded the growth of enteric fever Salmonellae, 29 S.Paratyphi A & 25 S.Typhi were isolated. Male to female ratio was 3:1, more commonly isolated in the first 3 decades. Seasonal variation was observed with majority of them isolated between July to September. Mean time for positive blood culture was 3-5 days.83.3% of the isolates were resistant to Nalidixic acid. MIC values of all isolates were in susceptible range but with increasing values. Conclusion: Enteric fever continues to be a major public health problem around Mysore. Paratyphoid fevers which were rarely detected previously have now emerged on par to more commonly susceptible. Ciprofloxacin resistance is not very common in this region

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