Histopathological And Biochemical Changes In Larvae Of Channa Punctatus Exposed To Thifluzamide

Abhimanyu Singh

Dr. Rittika Pandey

Dr. Anupma Kumari

Dr. Nirmala Tripathi

Vol. 9, Jan-Dec 2023

Page Number: 72 - 85

Abstract:

This study examines the histological and biochemical alterations in Channa punctatus larvae (spotted snakehead) subjected to different thifluzamide dosages. Several well-controlled lab investigations evaluated the effects on the liver, gills, and kidneys. Enzyme activity and protein levels in these organs were also investigated. Our experiment Channa punctatus larvae to different thifluzamide doses throughout time. Histopathology revealed cellular disintegration, tissue necrosis, and significant structural changes in vital organs such the liver, gills, and kidneys. Thorough liver tissue examination revealed vacuolation and hepatocellular deterioration. However, microscopic gill investigation showed lamellar fusion and epithelial elevation. Renal tissues exhibited extensive glomerular atrophy and tubular degeneration, suggesting renal function loss. The biochemical examination showed considerable enzyme activity and protein alterations, indicating biological system problems. ALT and AST levels increased significantly, indicating hepatic stress and liver failure. Furthermore, antioxidant enzymes like SOD and CAT showed changed activity, indicating oxidative stress responses. Tissue protein levels fluctuated throughout the study, suggesting disruptions in complex metabolic and protein synthesis networks that control cellular function. Importantly, thifluzamide may affect Channa punctatus larvae's growth and survival, according to studies. aquatic environment fungicide contamination ecological impacts. Histological and biochemical changes in fish species after extended thifluzamide exposure indicate that critical physiological processes are adversely impacted. These fascinating findings demonstrate long-term damage to diverse fish populations and aquatic biodiversity. This study underlines the necessity to closely control and monitor agricultural chemical products to decrease their environmental effect and conserve aquatic ecosystems' biodiversity.

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